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1 Oct 2010 Is cetirizine effective in canine allergic inhalant dermatitis, and, if so, what is the dosage? Tom McCoy, DVM. Harvard Avenue Veterinary Clinic. Zyrtec and Benadryl are well-known allergy treatments that have been proven to work. This guide provides a comparison of both medications so you can make A quick guide to follow to avoid complications from CBD drug interactions. Vets are starting to prescribe Zyrtec for dogs more and more often. They prescribe the drug to dogs to help reduce itching which is the popular symptom as well Can I take CBD Oil and an antihistamine, such as Zyrtec? : CBD Can I take CBD Oil and an antihistamine, such as Zyrtec? I am curious if I can take an antihistamine with CBD oil. It is my understanding that CBD oil inhibits the CYP450 Enzyme, which a majority of drugs are metabolized with/through.